Column selection helps to develop reproducible, rugged methods in the shortest possible time. With a variety of columns from which to choose, any method development lab can optimize selectivity, resolution and analysis time. The PAL Column Selector Valve Option allows a single or multiple users to select methods using appropriate column for their assay. Columns are stored in the storage solvent of choice requiring no manual changes. Different types of samples can be run over night using different columns resulting in better utilization of existing equipment. In a validated environment, PAL Column Selector Valve Option can be used for column reproducibility, method ruggedness or long-term stability.